学术报告：SAG101 forms a ternary complex with EDS1 and PAD4 and is required for resistance signaling against turnip crinkle virus
报告题目: SAG101 forms a ternary complex with EDS1 and PAD4 and is required for resistance signaling against turnip crinkle virus
报告人：Dr. Shifeng Zhu (University of Kentucky)
报告时间：2018年7月5日上午10:30-11:30
报告地点：动物所D122会议室
邀请人：张晓明
联系人：张晓明（010-64807550）
报告摘要：Plant immunity to pathogens requires several proteins, including EDS1, PAD4, and SAG101. These are thought to act downstream of resistance protein-mediated signaling. EDS1 interacts with both PAD4 and SAG101 but no interaction has been detected between SAG101 and PAD4. We found that SAG101 interacts with PAD4 via EDS1 and that the SAG101-EDS1-PAD4 ternary complex is present in the nucleus. We further show that Arabidopsis plants encode two functional isoforms of EDS1. Both isoforms interact with self and each other, as well as form ternary complexes. SAG101, which is thought to serve as a substitute for PAD4, functions independently in defense signaling against turnip crinkle virus. Our results suggest that EDS1, PAD4, SAG101 function independently as well as in a ternary complex to mediate plant defense signaling.
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